Saturday, April 13, 2013

TB in India

Introduction

The increasing come in of human immunodefi ciency virus (human immunodeficiency virus) infection in many countries has had an come to on tuberculosis (TB) epidemiology. While TB prevalence has remained stable, TB incidence continues to rise, especially in countries most severely modify by the human immunodeficiency virus plaguey as well as those facing political turmoil, migration, poverty and unemployment and where intravenous drug rib is rampant. human immunodeficiency virus is the most important known risk gene that promotes progression to agile TB in people with mycobacteria tuberculosis infection (TB/HIV A Clinical manual 2004). The lifetime risk of tuberculosis in immunocompetent persons is 5% to 10%, but in HIV positive individuals, there is a 5% to 15% annual risk of developing active TB disease (Swaminathan et al 2000). WHO estimated 9.2 million new cases of TB globally in 2006 (139 per 100,000); of whom 7,09,000 (7.7%) were HIV positive (World Health makeup 2008). India, China, Indonesia, South Africa and Nigeria rank fi rst to fi fth in terms of incident TB cases. In India, there were 2.5 million people living with HIV and AIDS (PLWHA) at the end of 2007 while the incidence of TB was approximately 1.8 million cases per year (WHO Release 2007, RNTCP 2008).

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In a survey carried out among new tuberculosis patients by the revise National TB manoeuvre Program (RNTCP) in 2007, HIV sero-prevalence varied widely and ranged from 1% to 13.8% across the 15 districts (Central TB Division, unpublished observations). Currently, it is not clear what role the HIV epidemic has played in the TB situation in India. If HIV prevalence in the community continues to increase, however, it could affect the TB control program, by decreasing cure rates and increasing mortality rate and recurrent TB. Further, appropriate management of patients with TB/HIV requires not only treating the tuberculosis but referring them for CD4...

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