Amyloid Protein Mediated Neurodegeneration in Alzheimers Disease Alzheimers Disease is a progressive, degenerative disease that affects the mentality. Individuals with AD experience a progressive and specific loss of cognitive betroth resulting from the differentiation of the limbic system, association neocortex, and basal fore maven. It is also tended to(p) by the deposition of amyloid in plaques and cerebrovasculature, and the governance of neurofibrillary tangles in neurons. Alois Alzheimer, a German doctor, diagnosed this disease for the first time in 1907. At that time it was considered a r be disorder. Currently, this tragic brain disorder affects approximately four million people; It is the near common type of dementia and the fourth leading shove along of death in the United States. Many studies have been do and ar still being conducted to determine the exact vitrine of AD. The molecular and biological basis for the degeneration of neurons in AD is incompletely understood. However, the APP(Amyloid Precursor Protein) and its proteolytic fragments have been implicated to a great extent often than not and is the focus of most catamenia studies. some(prenominal) lines of evidence have strengthened the amyloid hypothesis for Alzheimers Disease.
The first being the identification of point mutations with the APP gene in groups of patients afflicted with the familial forms of AD. Second, amyloid deposition temporally precedes the governance of neurofibrillary changes. In addition, b-amyloid has been shown to be toxic to neurons. In Alzheimers Disease, b-Amyloid proteins derive d from APP are the main component of neuriti! c plaques. It is believed that errantly processed APP derivatives may induce physiological processes that lead to neurodegeneration and plague formation. Many studies have success widey linked APP with AD. One study on transgenic mice with human APP717(associated with familial AD) displayed subcellular neurodegeneration interchangeable to those observed in AD, including dystrophic neurites,...If you want to get a to the full essay, order it on our website: OrderCustomPaper.com
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